In many ways, modifying RNA is just like formatting text in Microsoft Word
The Goh lab studies how RNA modifications (epitranscriptome) regulate gene expression and cellular processes by developing new technologies to sequence RNA modifications and functionally characterizing novel epitranscriptomic factors that interact with and metabolize RNA modifications. Defects in epitranscriptomic regulation cause a variety of diseases and determining the mechanistic basis that underlie these defects will be crucial for developing effective epitranscriptomic-based therapeutic strategies.
- Lab lunch @ haidilao to celebrate a few things
A big welcome to our new lab manager Camila, our new RA An and a summer visiting student Katherine. Best wishes too to our RA, Jenny who is heading off to begin her joint-PhD program with Hong Kong University. She will be gone for a few years but we look forward to her coming back to rejoin our lab for the 2nd half of her joint PhD.
- New algorithm for m6A mapping using direct-RNA sequencing
- Mohua joins as our 1st postdoc
As a joint-postdoc with the Ramanuj DasGupta lab, she will investigate how RNA methylation patterns affect colorectal cancer phenotypes.
- THE GOH LAB IS MOVING TO SHENZHEN, CHINA!!!
It has been a great and productive few years and the Goh lab will always remember its start in Singapore. Here’s to many more great years as we move over to the Institute of Molecular Physiology at the highly funded Shenzhen Bay Laboratory!
- First book chapter
- We found a new RNA methylation writer
Novel RNA-internal m6Am writer, Mettl4 and its role in regulating global splicing patterns through methylating U2 snRNA. A fruitful collaboration with the Xavier Roca lab at Nanyang Technological University. It also turns out that Xavi taught both Casslynn and Irvyn during their undergraduate years!
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