In many ways, modifying RNA is just like formatting text in Microsoft Word
The Goh lab studies how RNA modifications (epitranscriptome) regulate gene expression and cellular processes by developing new technologies to sequence RNA modifications and functionally characterizing novel epitranscriptomic factors that interact with and metabolize RNA modifications. Defects in epitranscriptomic regulation cause a variety of diseases and determining the mechanistic basis that underlie these defects will be crucial for developing effective epitranscriptomic-based therapeutic strategies.
LATEST NEWS
- 2022 Lab outing and pseudo-farewell for Ann
Finally got to do a real lab outing this year as well as a pseudo-farewell for our RA, Ann who is off to start her joint-PhD with HKU. We wish her all the best and look forward to her return for the 2nd half of the joint PhD!
- 1st NSFC grant for the lab
Sho got awarded the National Natural Science Foundation of China (NSFC) Research Fund for International Excellent Young Scientists to fund the development of RNA modification sequencing via 3rd generation sequencing.
- Singaporean scientist at SZ Bay Lab
Shenzhen Daily just did an interview with Sho, shining a spotlight on our lab members, the research that we do and why this is important to Shenzhen. Check it out!
- New algorithm for m6A mapping using direct-RNA sequencing
The fruits of our amazing collaboration with the Jonathan Goeke lab has yielded xPore, an algorithm that extracts m6A RNA modification sites from nanopore direct-RNA sequencing . Out now in Nature Biotechnology!
SZBL press release highlighting our work
Nature Reviews Genetics highlighting our work - Mohua joins as our 1st postdoc
As a joint-postdoc with the Ramanuj DasGupta lab, she will investigate how RNA methylation patterns affect colorectal cancer phenotypes.
- THE GOH LAB IS MOVING TO SHENZHEN, CHINA!!!
It has been a great and productive few years and the Goh lab will always remember its start in Singapore. Here’s to many more great years as we move over to the Institute of Molecular Physiology at the highly funded Shenzhen Bay Laboratory!
Find more news in our News Archive
Sho Goh Lab 